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Hawkins Lab
Center for Regenerative Medicine
Boston University and Boston Medical Center
The Hawkins Lab is interested in how the human lung is maintained and responds to injury. Induced pluripotent stem cells (iPSCs) offer a unique opportunity to model human lung disease and bridge the gap between research in animal models and humans. Using this iPSC platform we are focused on understanding the molecular mechanisms that control cell fate decisions and regenerative programs in the lungs. We hope to apply this knowledge to advance our understanding of and develop precision medicine approaches for lung disease. The lab has a particular focus on the airway epithelium and disease of the airways.
Latest publications:
2023: Airway regeneration via primary and iPSC derived basal cells in collaboration with the Kotton Lab: https://pubmed.ncbi.nlm.nih.gov/37625411/
2022: iPSC platform for Cystic Fibrosis disease modeling: https://www.nature.com/articles/s41467-022-31854-8
Check out or basal cell differentiation protocol here: https://star-protocols.cell.com/protocols/836
JOVE protocol for working with human iPSC-derived basal cells: https://www.jove.com/v/63882/generation-of-airway-epithelial-cell-airliquid-interface-cultures-from-human-pluripotent-stem-cells
Our 2021 Cell Stem Cell manuscript:
https://www.sciencedirect.com/science/article/pii/S1934590920304926?via%3Dihub
Team
Finn Hawkins, PI
Finn is a PI in the Center or Regenerative Medicine (CReM) at Boston University and Boston University Medical Center. He is also a Pulmonary and Critical Care attending in the Pulmonary Dept. of Boston University. Originally from Ireland, Finn moved to the US in 2007 to complete internal medicine residency at the Mayo Clinic, Rochester, MN followed by fellowship in Pulmonary/Critical Care Medicine at Boston University. During his fellowship he trained in Dr. Darrell Kotton's laboratory at a time when the derivation of lung lineages from iPSCs was in its infancy. This was the driving force that led Finn to pursue better models of human lung disease. Finn is the director of the Interstitial Lung Disease Clinic at. Boston Medical Center.
Andrew Berical, MD
Assistant Professor of Medicine
Andrew is a physician-scientist in the Hawkins lab. He recently applied iPS cells to model drug responsiveness for specific cystic fibrosis causing mutations (see Nature Communications manuscript above). He grew up in New York but is a New England transplant now. Away from the lab, he enjoys spending time with his family! Check out the culmination of Andrew's work in the 2022 Nature Communications manuscript (above). In 2022, Andrew received a Harry Schwachman Clinical Investigator Award from the Cystic Fibrosis Foundation.
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Jake Le Suer
Graduate student
Jake graduated Connecticut College in 2016 with a BA in biology and worked as a research assistant at Beth Israel Deaconess Medical Center prior to being accepted at BU. Jake's work focuses on the patterning of the developing foregut using iPSC directed differentiations. In separate work, Jake is studying the stem potential of human BCs. Outside of the lab Jake enjoys fishing, hiking, friends and family.
Taylor Matte
Graduate student
Taylor received his PhD with the Hawkins Lab in 2024. In his thesis work, Taylor seeks to develop a roadmap of lung specification and development by identifying the genetic programs controlling lung state and fate using the iPSC platform. He also seeks to compare this roadmap of normal development to a roadmap of aberrant development by probing the transcriptomic and phenotypic changes associated with mutations in key lung transcription factor, NKX2-1. Outside of the lab, Taylor enjoys trivia, physical activity, and an ice-cold margarita in the sun
DJ Wallman, MD
Assistant Professor, Pulmonary and Critical Care attending
DJ joined the Hawkins Lab in 2021 and is working on gene-editing of iPSC-derived basal cells to study primary ciliary dyskinesia. Outside of the lab, he enjoys spending time with new sons Mack and Jett, wife Kelly and dog Indiana while sneaking in soccer games and gardening when time permits
Mylène Gorzynski
Mylène is an MD PhD candidate and joined the Hawkins Lab in 2024
Alumni
-Anat Kohn, MD PhD: Pulmonary and Critical Care attending UPMC
-Gabrielle Cherfane, MD candidate
-Dylan Thomas MD, Orthopedic residency, University of Minnesota
News
Contact
For enquiries please contact Finn Hawkins at hawk@bu.edu. For lung differentiation protocols please visit:
http://www.bu.edu/dbin/stemcells/
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